Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Depression after Cerebral Infarction

Objective To explore the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on depression, cognitive function and activities daily living in patients with depression after cerebral infarction. Methods A total 50 infarction from departments neurology rehabilitation Second Affiliated Hospital Chongqing Medical University July 2018 to February 2020, which were randomly divided into control group observation group, 25 cases each group. All received conventional drug therapy, training, paroxetine antidepressant treatment. On this basis, was given sham stimulation, coil placed at 90 degrees perpendicular scalp, frequency 10.0 Hz, intensity 80%-90% resting motor threshold (RMT), adjusted low high according tolerance, two seconds per stimulus, 20 interval, pulses 1 200, once a day, five days week, continous treatment for six weeks. The rTMS treatment, site left dorsolateral prefrontal cortex (DLPFC), center point tangent scalp surface, parameters time same as those Before weeks, Montreal assessment scale (MoCA) used evaluate overall patients; Hamilton (HAMD) modified Barthel index (MBI) auditory event-related potential P300 adverse reactions groups compared. Results There no significant differences MoCA, HAMD, MBI scores between before (P>0.05). Compared MoCA scores, subitem (such visuospatial/executive function, attention/calculation) score both weeks significantly higher (P<0.05), HAMD latency lower, difference statistically (P<0.05). attention/calculation delayed memory) occurrence events Conclusion High can effectively improve depressive state post-stroke is worthy clinical application.